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The benzodiazepine story Leo H. Sternbach pp 1 - 7; DOI: 10.1021/jm00187a001 |
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[1-Penicillamine,2-leucine]oxytocin. Synthesis and pharmacological and conformational studies of a potent peptide hormone inhibitor Victor J. Hruby, K. K. Deb, Diane M. Yamamoto, Mac E. Hadley, and W. Y. Chan pp 7 - 12; DOI: 10.1021/jm00187a002 |
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Molecular orbital study on the reaction mechanism of irreversible enzyme inhibitors Chikayoshi Nagata and Tamie Yamaguchi pp 13 - 17; DOI: 10.1021/jm00187a003 |
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Structure-activity relationship in a new series of atropine analogs. 1. N,N'-Disubstituted 6,7-diazabicyclo[3.2.2]nonane derivatives Stephan Cherkez, Haim Yellin, Yoel Kashman, Bella Yaavetz, and Mordechai Sokolovsky pp 18 - 21; DOI: 10.1021/jm00187a004 |
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Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides Kyoichi A. Watanabe, Uri Reichman, Kosaku Hirota, Carlos Lopez, and Jack J. Fox pp 21 - 24; DOI: 10.1021/jm00187a005 |
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Preparation of the enantiomeric forms of 9-(5-deoxy-.alpha.-threo-pent-4-enofuranosyl)adenine and 9-(3,5-dideoxy-.beta.-D-glycero-pent-4-enofuranosyl)adenine and in vitro antileukemic screening Vinai K. Srivastava and Leon M. Lerner pp 24 - 28; DOI: 10.1021/jm00187a006 |
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Antileukemic activity of substituted ureidothiazoles, ureidothiadiazoles, and related compounds Robert K. Y. Zee-Cheng and C. C. Cheng pp 28 - 32; DOI: 10.1021/jm00187a007 |
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Ergot alkaloids. Synthesis of nitrosourea derivatives of ergolines as potential anticancer agents A. Michael Crider, Catherine K. L. Lu, Heinz G. Floss, John M. Cassady, and James A. Clemens pp 32 - 35; DOI: 10.1021/jm00187a008 |
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5-Iminodaunorubicin. Reduced cardiotoxic properties in an antitumor anthracycline George L. Tong, David W. Henry, and Edward M. Acton pp 36 - 39; DOI: 10.1021/jm00187a009 |
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Synthesis of daunorubicin analogs with novel 9-acyl substituents Thomas H. Smith, Allan N. Fujiwara, and David W. Henry pp 40 - 44; DOI: 10.1021/jm00187a010 |
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Development of ethyl 3,4-dihydro-4-oxopyrimido[4,5-b]quinoline-2-carboxylate, a new prototype with oral antiallergy activity T. H. Althuis, P. F. Moore, and H. J. Hess pp 44 - 48; DOI: 10.1021/jm00187a011 |
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Syntheses and antiinflammatory actions of 4,5,6,7-tetrahydroindazole-5-carboxylic acids Masahiko Nagakura, Tomio Ota, Noboru Shimidzu, Kiyoshi Kawamura, Yoshinori Eto, and Yasushi Wada pp 48 - 52; DOI: 10.1021/jm00187a012 |
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A new nonsteroidal analgesic-antiinflammatory agent. Synthesis and activity of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone and related compounds M. Takaya, M. Sato, K. Terashima, H. Tanizawa, and Y. Maki pp 53 - 58; DOI: 10.1021/jm00187a013 |
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Studies on analgesic agents. 1. Preparation of 1,2-diphenyl-2-(4-substituted 1-piperazinyl)ethanol derivatives and structure-activity relationships Noriaki Shimokawa, Hideo Nakamura, Keiko Shimakawa, Hideo Minami, and Haruki Nishimura pp 58 - 63; DOI: 10.1021/jm00187a014 |
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Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogs Michael E. Flaugh, Thomas A. Crowell, James A. Clemens, and Barry D. Sawyer pp 63 - 69; DOI: 10.1021/jm00187a015 |
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Hypobetalipoproteinemic agents. 2. Compounds related to 4-(1-adamantyloxy)aniline Daniel Lednicer, William E. Heyd, D. Edward Emmert, Ruth E. TenBrink, Paul E. Schurr, and Charles E. Day pp 69 - 77; DOI: 10.1021/jm00187a016 |
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2-Indanpropionic acids: structural leads for prostaglandin F2.alpha. antagonist development Donald T. Witiak, Sunil V. Kadodkar, Timothy P. Johnson, John R. Baldwin, and Ralf G. Rahwan pp 77 - 81; DOI: 10.1021/jm00187a017 |
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Relationship of nonspecific antiarrhythmic and negative inotropic activity with physicochemical parameters of propranolol analogs David O. Rauls and John K. Baker pp 81 - 86; DOI: 10.1021/jm00187a018 |
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Antimalarials. 4. Trichloronaphthalene amino alcohols Dwight A. Shamblee and J. Samuel Gillespie pp 86 - 89; DOI: 10.1021/jm00187a019 |
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Discriminant-analytical investigation on the structural dependence of hyperglycemic and hypoglycemic activity in a series of substituted o-toluenesulfonylthioureas and o-toluenesulfonylureas S. Dove, R. Franke, O. L. Mndshojan, W. A. Schkuljev, and L. W. Chashakjan pp 90 - 95; DOI: 10.1021/jm00187a020 |
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Studies on biologically active halogenated compounds. 1. Synthesis and central nervous system depressant activity of 2-(fluoromethyl)-3-aryl-4(3H)-quinazolinone derivatives Junichi Tani, Yoshihisa Yamada, Toyonari Oine, Takashi Ochiai, Ryuichi Ishida, and Ichizo Inoue pp 95 - 99; DOI: 10.1021/jm00187a021 |
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Kojic amine - a novel .gamma.-aminobutyric acid analog Joseph G. Atkinson, Yves Girard, J. Rokach, C. S. Rooney, C. S. McFarlane, A. Rackham, and N. N. Share pp 99 - 106; DOI: 10.1021/jm00187a022 |
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Synthesis and evaluation for diuretic activity of 1-substituted 6-chloro-5-sulfamylindolines Edward J. Glamkowski and Philip A. Reitano pp 106 - 109; DOI: 10.1021/jm00187a023 |
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Phosphonate analog of 2'-deoxy-5-fluorouridylic acid John A. Montgomery, H. Jeanette Thomas, Roy L. Kisliuk, and Yvette Gaumont pp 109 - 111; DOI: 10.1021/jm00187a024 |
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Correlation of carbonic anhydrase inhibitory activities of benzenesulfonamides with the data obtained by use of nitrogen-14 nuclear quadrupole resonance S. N. Subbarao and P. J. Bray pp 111 - 114; DOI: 10.1021/jm00187a025 |
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11-Oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid, an orally active antiallergy agent Charles F. Schwender, Brooks R. Sunday, and David J. Herzig pp 114 - 116; DOI: 10.1021/jm00187a026 |
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Actions of two dopamine derivatives at adreno- and cholinoceptors I. W. Rodger, A. S. Hersom, and R. D. Waigh pp 117 - 119; DOI: 10.1021/jm00187a027 |
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Apparent bioisosteric replacement of -S- by NCN: synthesis of N-cyano-2-aza-A-nor-5.alpha.-androstan-17.beta.-ol acetate, an aza steroid androgen Wen-Hsiung Chiu, Thomas H. Klein, and Manfred E. Wolff pp 119 - 120; DOI: 10.1021/jm00187a028 |
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Synthesis and antitumor activity of 4'-O-methyldaunorubicin, 4'-O-methyladriamycin, and their 4'-epi analogs G. Cassinelli, D. Ruggieri, and F. Arcamone pp 121 - 123; DOI: 10.1021/jm00188a001 |
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1,3,5-Tris(N,N',N"-2,3-dihydroxybenzoyl)aminomethylbenzene, a synthetic iron chelator related to enterobactin Michael C. Venuti, William H. Rastetter, and J. B. Neilands pp 123 - 124; DOI: 10.1021/jm00188a002 |
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3-Substituted adenines. In vitro enzyme inhibition and antiviral activity Tozo Fujii, Graham C. Walker, Nelson J. Leonard, Donald C. DeLong, and Koert Gerzon pp 125 - 129; DOI: 10.1021/jm00188a003 |
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Structural requirements for progestational activity. Synthesis and properties of rac-8.alpha.,9.beta.,10.alpha.14.beta.-progesterone A. J. Solo, Virendra Kumar, Vitauts Alks, and William L. Duax pp 129 - 133; DOI: 10.1021/jm00188a004 |
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Potential antitumor agents. 29. Quantitative structure-activity relationships for the antileukemic bisquaternary ammonium heterocycles William A. Denny, Graham J. Atwell, Bruce C. Baguley, and Bruce F. Cain pp 134 - 150; DOI: 10.1021/jm00188a005 |
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Synthesis and antitumor activity of cyclophosphamide analogs. 2. Preparation, hydrolytic studies, and anticancer screening of 5-bromocyclophosphamide, 3,5-dehydrocyclophosphamide, and related systems Susan Marie Ludeman, Gerald Zon, and William Egan pp 151 - 158; DOI: 10.1021/jm00188a006 |
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Aryloxyalkyloxy- and aralkyloxy-4-hydroxy-3-nitrocoumarins which inhibit histamine release in the rat and also antagonize the effects of a slow reacting substance of anaphylaxis Derek R. Buckle, D. James Outred, Janet W. Ross, Harry Smith, Raymond J. Smith, Barbara A. Spicer, and Brian C. Gasson pp 158 - 168; DOI: 10.1021/jm00188a007 |
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Synthesis and pharmacologic characterization of an alkylating analog chlornaltrexamine, of naltrexone with ultralong-lasting narcotic antagonist properties P. S. Portoghese, D. L. Larson, J. B. Jiang, T. P. Caruso, and A. E. Takemori pp 168 - 173; DOI: 10.1021/jm00188a008 |
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Optically pure (+)-nicotine from (.+-.)-nicotine and biological comparisons with (-)-nicotine Mario D. Aceto, Billy R. Martin, Ibrahim M. Uwaydah, Everette L. May, Louis S. Harris, Consuelo Izazola-Conde, William L. Dewey, Thomas J. Bradshaw, and W. C. Vincek pp 174 - 177; DOI: 10.1021/jm00188a009 |
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Synthesis of pyridinium analogs of acetylcholine and their interactions with intestinal muscarinic receptors Dida Kuhnen-Clausen, Ilse Hagedorn, and Rudolf Bill pp 177 - 180; DOI: 10.1021/jm00188a010 |
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Studies on 3-substituted 1,2-benzisoxazole derivatives. 6. Syntheses of 3-(sulfamoylmethyl)-1,2-benzisoxazole derivatives and their anticonvulsant activities Hitoshi Uno, Mikio Kurokawa, Yoshinobu Masuda, and Haruki Nishimura pp 180 - 183; DOI: 10.1021/jm00188a011 |
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Azetidine derivatives of tricyclic antidepressant agents Piero Melloni, Arturo Della Torre, Maurizio Meroni, Anna Ambrosini, and Alessandro C. Rossi pp 183 - 191; DOI: 10.1021/jm00188a012 |
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Easily hydrolyzable, water-soluble derivatives of (.+-.)-.alpha.-5-[1-(indol-3-yl)ethyl]-2-methylamino-.DELTA.2-thiazolin-4-one, a novel antiviral compound Michael R. Harnden, Stuart Bailey, Malcolm R. Boyd, J. Bruce Wilkinson, and Nicholas D. Wright pp 191 - 195; DOI: 10.1021/jm00188a013 |
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Electrochemical oxidation of hydroxylated phenothiazine and imipramine derivatives Marilyn Neptune, Richard L. McCreery, and Albert A. Manian pp 196 - 199; DOI: 10.1021/jm00188a014 |
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Synthesis of steroidal nitrosoureas with antitumor activity Hing-Yat P. Lam, Asher Begleiter, Gerald J. Goldenberg, and Chiu-Ming Wong pp 200 - 202; DOI: 10.1021/jm00188a015 |
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Phototoxicity of chlorpromazine Nigel J. Bunce, Yogesh Kumar, and Luis Ravanal pp 202 - 204; DOI: 10.1021/jm00188a016 |
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Aminotetralins as narcotic antagonists. Synthesis and opiate-related activity of 1-phenyl-1-aminotetralin derivatives William G. Reifenrath and David S. Fries pp 204 - 206; DOI: 10.1021/jm00188a017 |
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Bicyclic pyrazolines, potential central nervous system depressants and antiinflammatory agents John Krapcho and Chester F. Turk pp 207 - 210; DOI: 10.1021/jm00188a018 |
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Synthesis and preliminary biological studies of 4- and 5-[2-hydroxy-3-(isopropylamino)propoxy]benzimidazoles: selective β2 adrenergic blocking agents C. Richard Crooks, Jeremy Wright, Patrick S. Callery, and J. Edward Moreton pp 210 - 214; DOI: 10.1021/jm00188a019 |
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Book Reviews pp 214 - 214; DOI: 10.1021/jm00188a600 |
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Conformational analysis of podophyllotoxin and its congeners. Structure-activity relationship in microtubule assembly C. Fred Brewer, John D. Loike, Susan B. Horwitz, Himan Sternlicht, and Walter J. Gensler pp 215 - 221; DOI: 10.1021/jm00189a001 |
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A model for thyroid hormone-receptor interactions Tariq A. Andrea, Stephen W. Dietrich, Wallace J. Murray, Peter A. Kollman, Eugene C. Jorgensen, and Steve Rothenberg pp 221 - 232; DOI: 10.1021/jm00189a002 |
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Coenzyme-substrate adducts as inhibitors of mouse liver 3,4-dihydroxyphenylalanine decarboxylase E. A. Rudd, W. C. Cunningham, and J. W. Thanassi pp 233 - 237; DOI: 10.1021/jm00189a003 |
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Cyclic amidine inhibitors of indolamine N-methyltransferase Joshua Rokach, Pierre Hamel, Norman R. Hunter, Grant Reader, Clarence S. Rooney, Paul S. Anderson, Edward J. Cragoe, and Lewis R. Mandel pp 237 - 247; DOI: 10.1021/jm00189a004 |
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Synthesis and activities of antitumor agents Tetsuo Suami, Tomoya Machinami, and Takashi Hisamatsu pp 247 - 250; DOI: 10.1021/jm00189a005 |
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Potential antitumor agents. 30. Mutagenic activity of some 9-anilinoacridines: relationships between structure, mutagenic potential, and antileukemic activity Lynnette R. Ferguson and William A. Denny pp 251 - 255; DOI: 10.1021/jm00189a006 |
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Deoxymorphines: role of the phenolic hydroxyl in antinociception and opiate receptor interactions Juergen Reden, Marvin F. Reich, Kenner C. Rice, Arthur E. Jacobson, Arnold Brossi, Richard A. Streaty, and Werner A. Klee pp 256 - 259; DOI: 10.1021/jm00189a007 |
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Metabolic oxidation of nicotine to chemically reactive intermediates Trong Lang Nguyen, Larry D. Gruenke, and Neal Castagnoli Jr. pp 259 - 263; DOI: 10.1021/jm00189a008 |
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Antiallergy agents. 1. 1,6-Dihydro-6-oxo-2-phenylpyrimidine-5-carboxylic acids and esters Peter F. Juby, Thomas W. Hudyma, Myron Brown, John M. Essery, and Richard A. Partyka pp 263 - 269; DOI: 10.1021/jm00189a009 |
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Synthesis and some pharmacological properties of 8-L-methionine-oxytocin Miklos Bodanszky, Nagarajan Chandramouli, Jean Martinez, and Roderich Walter pp 270 - 273; DOI: 10.1021/jm00189a010 |
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Prodrugs of 9-(.beta.-D-arabinofuranosyl)adenine. 2. Synthesis and evaluation of a number of 2',3'- and 3',5'-di-O-acyl derivatives David C. Baker, Theodore H. Haskell, Sterling R. Putt, and Bernard J. Sloan pp 273 - 279; DOI: 10.1021/jm00189a011 |
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New bronchodilators. Synthesis and bronchodilating activity of some 3-(alkoxymethyl)-.alpha.-(N-substituted aminomethyl)-4-hydroxybenzyl alcohols Shigeru Sohda, Masatoshi Fujimoto, Tomozo Tamegai, and Noriyasu Hirose pp 279 - 286; DOI: 10.1021/jm00189a012 |
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Cardenolide analogs. 9. Synthesis and biological activity of 17.beta.-carbomethoxyethylene and 17.beta.-cyanoethylene 14.alpha.-H steroids Alex Gelbart, John Boutagy, and Richard Thomas pp 287 - 290; DOI: 10.1021/jm00189a013 |
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Studies on antianaphylactic agents. 6. Synthesis of some metabolites of 6-ethyl-3-(1H-tetrazol-5-yl)chromone and their analogs Akira Nohara, Hisashi Kuriki, Toshihiro Ishiguro, Taketoshi Saijo, Kiyoshi Ukawa, Yoshitaka Maki, and Yasushi Sanno pp 290 - 295; DOI: 10.1021/jm00189a014 |
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2-Mercaptoacetamidines as gastric antisecretory agents William A. Bolhofer, Charles N. Habecker, Adolph M. Pietruszkiewicz, Mary Lou Torchiana, Henry I. Jacoby, and Clement A. Stone pp 295 - 301; DOI: 10.1021/jm00189a015 |
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Inhibition of gastric acid secretion by 1,8-naphthyridin-2(1H)-ones William A. Bolhofer, Jacob M. Hoffman, Charles N. Habecker, Adolph M. Pietruszkiewicz, Edward J. Cragoe, and Mary Lou Torchiana pp 301 - 306; DOI: 10.1021/jm00189a016 |
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An attempt to apply lethal synthesis to the design of chemotherapeutic agents. Fluorinated 5.beta.-(hydroxyethyl)-4-methylthiazoles Sydney Archer and Cecily Perianayagam pp 306 - 309; DOI: 10.1021/jm00189a017 |
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Prodrug analogs of the antitumor alkaloid camptothecin John A. Adamovics and C. Richard Hutchinson pp 310 - 314; DOI: 10.1021/jm00189a018 |
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Synthesis and antitumor activity of water-soluble (2-chloroethyl)nitrosoureas Tetsuo Suami, Kinichi Tadano, and William T. Bradner pp 314 - 316; DOI: 10.1021/jm00189a019 |
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5-Substituted uracil arabinonucleosides as potential antiviral agents P. F. Torrence, G. F. Huang, M. W. Edwards, B. Bhooshan, J. Descamps, and E. De Clercq pp 316 - 319; DOI: 10.1021/jm00189a020 |
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Enzyme affinity of the 5,6-dihydro derivatives of the substrate and product of thymidylate synthetase catalysis Joon Sup Park, Charles T. C. Chang, and Mathias P. Mertes pp 319 - 321; DOI: 10.1021/jm00189a021 |
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Preparation and antidiabetic activity of some sulfonylurea derivatives of 3,5-disubstituted pyrazoles Raafat Soliman pp 321 - 325; DOI: 10.1021/jm00189a022 |
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Differential solubilities in subregions of the membrane: a nonsteric mechanism of drug specificity Emmanuel M. Landau, Jacob Richter, and Sasson Cohen pp 325 - 327; DOI: 10.1021/jm00189a023 |
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Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids Arthur E. Jacobson, Kenner C. Rice, Juergen Reden, Lillian Lupinacci, Arnold Brossi, Richard A. Streaty, and Werner A. Klee pp 328 - 331; DOI: 10.1021/jm00189a024 |
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Conformations, DNA binding parameters, and antileukemic activity of certain cytotoxic protoberberine alkaloids Mark Cushman, Frederick W. Dekow, and Linda B. Jacobsen pp 331 - 333; DOI: 10.1021/jm00189a025 |
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Synthesis and pharmacological properties of [5-isoleucine]-, [8-isoleucine]-, and [5,8-diisoleucine]bradykinin Andrew T. Chiu, Alan R. Day, Jeffrey A. Radding, and Richard J. Freer pp 334 - 335; DOI: 10.1021/jm00189a026 |
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Book Reviews pp 336 - 338; DOI: 10.1021/jm00189a600 |
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Trans-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridylate: a mechanism-based inhibitor of thymidylate synthetase Yusuke Wataya, Akira Matsuda, Daniel V. Santi, Donald E. Bergstrom, and Jerry L. Ruth pp 339 - 340; DOI: 10.1021/jm00190a001 |
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Rigid congeners of dopamine based on octahydrobenzo[f]quinoline: peripheral and central effects Joseph G. Cannon, Cecilia Suarez-Gutierrez, Teresa Lee, John Paul Long, Brenda Costall, David H. Fortune, and Robert J. Naylor pp 341 - 347; DOI: 10.1021/jm00190a002 |
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Drug-induced modifications of the immune response. 1. Substituted 1-phenylisoquinolines V. S. Georgiev, Richard P. Carlson, Richard G. Van Inwegen, and Atul Khandwala pp 348 - 352; DOI: 10.1021/jm00190a003 |
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Inhibition of uptake of catecholamines by benzylamine derivatives R. Craig Kammerer, Bahman Amiri, and Arthur K. Cho pp 352 - 355; DOI: 10.1021/jm00190a004 |
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3-Substituted pyrazole derivatives as inhibitors and inactivators of liver alcohol dehydrogenase Richard W. Fries, David P. Bohlken, and Bryce V. Plapp pp 356 - 359; DOI: 10.1021/jm00190a005 |
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Quantitative structure-activity relationships for biguanides, carbamimidates, and bisbiguanides as inhibitors of Streptococcus mutans No. 6715 Victor D. Warner, Donald M. Lynch, Ki Hwan Kim, and Gary L. Grunewald pp 359 - 366; DOI: 10.1021/jm00190a006 |
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Quantitative structure-activity relationships in 1-aryl-2-(alkylamino)ethanol antimalarials Ki Hwan Kim, Corwin Hansch, James Y. Fukunaga, Edward E. Steller, Priscilla Y. C. Jow, Paul N. Craig, and June Page pp 366 - 391; DOI: 10.1021/jm00190a007 |
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Structure-activity relationships of dimeric Catharanthus alkaloids. 2. Experimental antitumor activities of N-substituted deacetylvinblastine amide (vindesine) sulfates Robert A. Conrad, George J. Cullinan, Koert Gerzon, and Gerald A. Poore pp 391 - 400; DOI: 10.1021/jm00190a008 |
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Use of the butaclamol template in a search for antipsychotic agents with lessened side effects Michael J. Kukla, James L. Bloss, and Linda R. Brougham pp 401 - 406; DOI: 10.1021/jm00190a009 |
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Synthesis and antitumor activity of sugar-ring hydroxyl analogs of daunorubicin Ernst F. Fuchs, Derek Horton, Wolfgang Weckerle, and Eva Winter-Mihaly pp 406 - 411; DOI: 10.1021/jm00190a010 |
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Antianaphylactic agents. 1. 2-(Acylamino)oxazoles W. J. Ross, R. G. Harrison, M. R. J. Jolley, M. C. Neville, A. Todd, J. P. Verge, W. Dawson, and W. J. F. Sweatman pp 412 - 417; DOI: 10.1021/jm00190a011 |
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Pharmacologically active sulfoximides: 5-hexyl-7-(S-methylsulfonimidoyl)xanthone-2-carboxylic acid, a potent antiallergic agent Alan C. Barnes, Peter W. Hairsine, Saroop S. Matharu, Peter J. Ramm, and John B. Taylor pp 418 - 424; DOI: 10.1021/jm00190a012 |
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Biological properties of transition-metal organometallic compounds. 3. .beta.-Ferrocenylalanine Robert P. Hanzlik, Phyllis Soine, and William H. Soine pp 424 - 428; DOI: 10.1021/jm00190a013 |
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Serotonin receptor binding affinities of tryptamine analogs Richard A. Glennon and Peter K. Gessner pp 428 - 432; DOI: 10.1021/jm00190a014 |
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Aminoglycoside antibiotics. 2. N, N-Dialkylkanamycins Virendra Kumar and William A. Remers pp 432 - 436; DOI: 10.1021/jm00190a015 |
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Novel application of proton nuclear magnetic resonance spectroscopy in the identification of 2'-chloronordiazepam metabolites in the dog Thomas H. Williams, Gino J. Sasso, John J. Ryan, and Morton A. Schwartz pp 436 - 440; DOI: 10.1021/jm00190a016 |
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.beta.-Adrenoceptor studies. 5. Proton NMR and IR spectroscopic analysis of the conformation of the hydrohalide salts of .beta.-adrenoceptor-blocking aryloxypropanolamines. Evidence for a seven-membered ring structure with participation of two hydrogen bonds Johan Zaagsma pp 441 - 449; DOI: 10.1021/jm00190a017 |
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Potential organ- or tumor-imaging agents. 18. Radioiodinated diamines and bisquaternaries C. C. Huang, N. Korn, and R. E. Counsell pp 449 - 452; DOI: 10.1021/jm00190a018 |
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A new chemical series active against African trypanosomes: benzyltriphenylphosphonium salts Kenneth E. Kinnamon, Edgar A. Steck, and Dora S. Rane pp 452 - 455; DOI: 10.1021/jm00190a019 |
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Synthesis and pharmacological activity of 2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepines Paul H. Mazzocchi and Barbara C. Stahly pp 455 - 457; DOI: 10.1021/jm00190a020 |
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Resolution and absolute configuration of trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine, a potent hallucinogen analog David E. Nichols, Ronald Woodard, Bruce A. Hathaway, Martin T. Lowy, and George K. W. Yim pp 458 - 460; DOI: 10.1021/jm00190a021 |
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Book Reviews pp 461 - 462; DOI: 10.1021/jm00190a600 |
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Propiolaldehyde, a pargyline metabolite that irreversibly inhibits aldehyde dehydrogenase. Isolation from a hepatic microsomal system Frances N. Shirota, Eugene G. DeMaster, and Herbert T. Nagasawa pp 463 - 464; DOI: 10.1021/jm00191a001 |
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Classification of drugs by discriminant analysis using fragment molecular connectivity values Douglas R. Henry and John H. Block pp 465 - 472; DOI: 10.1021/jm00191a002 |
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Ames test of 1-(X-phenyl)-3,3-dialkyltriazenes. A quantitative structure-activity study Benjamin H. Venger, Corwin Hansch, Gerard J. Hatheway, and Yost U. Amrein pp 473 - 476; DOI: 10.1021/jm00191a003 |
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Computer-assisted structure-activity studies of chemical carcinogens. A heterogeneous data set Peter C. Jurs, J. T. Chou, and M. Yuan pp 476 - 483; DOI: 10.1021/jm00191a004 |
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Multivariate analysis and quantitative structure-activity relationships. Inhibition of dihydrofolate reductase and thymidylate synthetase by quinazolines Bor-Kuan Chen, Csaba Horvath, and Joseph R. Bertino pp 483 - 491; DOI: 10.1021/jm00191a005 |
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Quantitative structure-activity relationships in 2,5-bis(1-aziridinyl)-p-benzoquinone derivatives against leukemia L-1210 Masafumi Yoshimoto, Hachio Miyazawa, Hideo Nakao, Kenkichi Shinkai, and Masao Arakawa pp 491 - 496; DOI: 10.1021/jm00191a006 |
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Alkylating nucleosides. 1. Synthesis and cytostatic activity of N-glycosyl(halomethyl)-1,2,3-triazoles. A new type of alkylating agent Federico G. De las Heras, Rosario Alonso, and Gregorio Alonso pp 496 - 501; DOI: 10.1021/jm00191a007 |
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Structural modification study of bis(substituted aminoalkylamino)anthraquinones. An evaluation of the relationship of the [2-[(2-hydroxyethyl)amino]ethyl]amino side chain with antineoplastic activity Robert K. Y. Zee-Cheng, Eugene G. Podrebarac, C. S. Menon, and C. C. Cheng pp 501 - 505; DOI: 10.1021/jm00191a008 |
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Synthesis of 3,4-dihydro-4-oxothieno[2,3-d]pyrimidine-2-carboxylates, a new series of orally active antiallergy agents D. L. Temple, J. P. Yevich, R. R. Covington, C. A. Hanning, R. J. Seidehamel, H. K. Mackey, and M. J. Bartek pp 505 - 510; DOI: 10.1021/jm00191a009 |
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Antiviral activity of aliphatic nucleoside analogs: structure-function relationship E. De Clercq and A. Holy pp 510 - 513; DOI: 10.1021/jm00191a010 |
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Synthesis and antitumor and antiviral activities of 1-.beta.-D-arabinofuranosyl-2-amino-1,4(2H)-iminopyrimidine, and its derivatives A. Mohsin Mian, Robert A. Long, Lois B. Allen, Robert W. Sidwell, Roland K. Robins, and Tasneem A. Khwaja pp 514 - 518; DOI: 10.1021/jm00191a011 |
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Improved antitumor effects in 3'-branched homologs of 2'-deoxythioguanine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose Edward M. Acton, Richard N. Goerner, Hong S. Uh, Kenneth J. Ryan, David W. Henry, Carol E. Cass, and Gerald A. LePage pp 518 - 525; DOI: 10.1021/jm00191a012 |
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Synthesis and platelet aggregation inhibitory activity of 6-isobutyl-.alpha.-methyl-3-pyridineacetic acid Ronald H. Rynbrandt, Burris D. Tiffany, Doris P. Balgoyen, Edward E. Nishizawa, and A. Rene Mendoza pp 525 - 528; DOI: 10.1021/jm00191a013 |
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Cardenolide analogs. 4. (20R)- and (20S)-cardanolides: on the roles of the 20(22)-ene and 14.beta.-hydroxyl in genin activity Dwight S. Fullerton, Kouichi Yoshioka, Douglas C. Rohrer, Arthur H. L. From, and Khalil Ahmed pp 529 - 533; DOI: 10.1021/jm00191a014 |
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Conformational analogy between .beta.-lactam antibiotics and tetrahedral transition states of dipeptide Donald B. Boyd pp 533 - 537; DOI: 10.1021/jm00191a015 |
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Syntheses, analgetic activity and physical dependence capacity of 5-phenyl-6,7-benzomorphan derivatives Naokata Yokoyama, Prabodh I. Almaula, Fred B. Block, Frank R. Granat, Norman Gottfried, Ronald T. Hill, Elihu H. McMahon, Walter F. Munch, Howard Rachlin, and et al. pp 537 - 553; DOI: 10.1021/jm00191a016 |
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Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates Philippe M. Manoury, Andre P. Dumas, Henry Najer, Dan Branceni, Monique Prouteau, and Francoise M. Lefevre-Borg pp 554 - 559; DOI: 10.1021/jm00191a017 |
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Synthesis and antibacterial activity of 2'-substituted chelocardin analogs David L. Garmaise, Daniel T. W. Chu, Edith Bernstein, and Makoto Inaba pp 559 - 564; DOI: 10.1021/jm00191a018 |
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Synthetic antagonists of in vivo responses by the rat uterus to oxytocin John Lowbridge, Maurice Manning, Jenny Seto, Jaya Haldar, and Wilbur H. Sawyer pp 565 - 569; DOI: 10.1021/jm00191a019 |
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Synthesis and chemical carcinogen inhibitory activity of 2-tert-butyl-4-hydroxyanisole Luke K. T. Lam, Ramdas P. Pai, and Lee W. Wattenberg pp 569 - 571; DOI: 10.1021/jm00191a020 |
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Biomolecules bearing the S- or SeAsMe2 function: amino acid and steroid derivatives Catherine H. Banks, James R. Daniel, and Ralph A. Zingaro pp 572 - 575; DOI: 10.1021/jm00191a021 |
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Platinum and palladium derivatives for chemotherapy studies Carl Tabb Bahner, Truett C. Patterson, Lydia M. Rives, and Harry D. Harmon pp 575 - 577; DOI: 10.1021/jm00191a022 |
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Synthesis of all the stereoisomers of statine (4-amino-3-hydroxy-6-methylheptanoic acid). Inhibition of pepsin activity by N-carbobenzoxy-L-valyl-L-valyl-statine derived from the four stereoisomers W. S. Liu, S. C. Smith, and G. I. Glover pp 577 - 579; DOI: 10.1021/jm00191a023 |
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Synthesis and biologic distribution of mercapto derivatives of palmitic acid Eli Livni, Michael A. Davis, and Victor D. Warner pp 580 - 583; DOI: 10.1021/jm00191a024 |
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Potential radiosensitizing agents. Dinitroimidazoles Krishna C. Agrawal, Kathleen B. Bears, Raj K. Sehgal, Joe N. Brown, Patricia E. Rist, and W. D. Rupp pp 583 - 586; DOI: 10.1021/jm00191a025 |
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Synthesis of a proposed thymic factor Robert G. Strachan, William J. Paleveda, Susan J. Bergstrand, Ruth F. Nutt, Frederick W. Holly, and Daniel F. Veber pp 586 - 588; DOI: 10.1021/jm00191a026 |
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Synthesis of hydroxy- and amino-substituted benzohydroxamic acids: inhibition of ribonucleotide reductase and antitumor activity Bart Van't Riet, Galen L. Wampler, and Howard L. Elford pp 589 - 592; DOI: 10.1021/jm00191a027 |
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Synthesis and biological activity of 5-fluoro- and 5-methyl-1,3-oxazine-2,6(3H)-dione M. Bobek, S. Kuhar, and A. Bloch pp 592 - 594; DOI: 10.1021/jm00191a028 |
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A structural modification study of procarbazine Louis T. Weinstock and C. C. Cheng pp 594 - 597; DOI: 10.1021/jm00191a029 |
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L-Chlorozotocin Thomas P. Johnston, George S. McCaleb, Tom Anderson, and Donald S. Murinson pp 597 - 599; DOI: 10.1021/jm00191a030 |
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1-(Dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinol esters. New potent antiamebic agents Denis M. Bailey, Eldridge M. Mount, James Siggins, John A. Carlson, Allen Yarinsky, and Ralph G. Slighter pp 599 - 601; DOI: 10.1021/jm00191a031 |
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Book Reviews pp 601 - 602; DOI: 10.1021/jm00191a600 |
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Intramolecular hydrogen bonding and conformational studies of bridged thebaine and oripavine opiate narcotic agonists and antagonists Gilda H. Loew and Donald S. Berkowitz pp 603 - 607; DOI: 10.1021/jm00192a001 |
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Quantitative structure-activity relationships involving the inhibition of glycolic acid oxidase by derivatives of glycolic and glyoxylic acids William C. Randall, Kermit B. Streeter, Emlen L. Cresson, Harvey Schwam, Stuart R. Michelson, Paul S. Anderson, Edward J. Cragoe, Haydn W. R. Williams, Eva Eichler, and C. Stanley Rooney pp 608 - 614; DOI: 10.1021/jm00192a002 |
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Quantitative structure-activity relationship of 5-(X-benzyl)-2,4-diaminopyrimidines inhibiting bovine liver dihydrofolate reductase Jeffrey M. Blaney, Stephen W. Dietrich, Mark A. Reynolds, and Corwin Hansch pp 614 - 617; DOI: 10.1021/jm00192a003 |
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Synthesis of 5-selenium-substituted uracil derivatives. Inhibition of thymidylate synthetase by 5-hydroseleno-2'-deoxyuridylate Seyuen Choi, T. I. Kalman, and T. J. Bardos pp 618 - 621; DOI: 10.1021/jm00192a004 |
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Design of species- or isozyme-specific enzyme inhibitors. I. Effect of thymidine substituents on affinity for the thymidine site of hamster cytoplasmic thymidine kinase Alexander Hampton, Francis Kappler, and Ram R. Chawla pp 621 - 631; DOI: 10.1021/jm00192a005 |
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S-2,.omega.-Diaminoalkyl dihydrogen phosphorothioates as antiradiation agents James R. Piper, Lucy M. Rose, Thomas P. Johnston, and Marie M. Grenan pp 631 - 639; DOI: 10.1021/jm00192a006 |
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Studies on biologically active nucleosides and nucleotides. 5. Synthesis and antitumor activity of some 2,2'-anhydro-1-(3',5'-di-O-acyl-.beta.-D-arabinofuranosyl)cytosine salts and 2,2'-anhydro-1-(3'-O-acyl-.beta.-D-arabinofuranosyl)cytosine 5'-phosphates Kazuhiko Kondo, Takeo Nagura, Yoshihisa Arai, and Ichizo Inoue pp 639 - 646; DOI: 10.1021/jm00192a007 |
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Synthesis and antiviral activities of arabinofuranosyl-5-ethylpyrimidine nucleosides. Selective antiherpes activity of 1-(.beta.-D-arabinofuranosyl)-5-ethyluracil Tadeusz Kulikowski, Zbigniew Zawadzki, David Shugar, Johan Descamps, and Erik De Clercq pp 647 - 653; DOI: 10.1021/jm00192a008 |
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Studies on the mechanism of antiviral action of 1-(.beta.-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (ribavirin) Alicja K. Drabikowska, Lech Dudycz, and David Shugar pp 653 - 657; DOI: 10.1021/jm00192a009 |
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Orally active esters of cephalosporin antibiotics. 3. Synthesis and biological properties of aminoacyloxymethyl esters of 7-[D-(-)-mandelamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylic acid W. J. Wheeler, D. A. Preston, W. E. Wright, G. W. Huffman, H. E. Osborne, and D. P. Howard pp 657 - 661; DOI: 10.1021/jm00192a010 |
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Chemical and biological studies of 1-(2,5-dihydroxy-4-methylphenyl)-2-aminopropane, an analog of 6-hydroxydopamine Peyton Jacob, Toni Kline, and Neal Castagnoli pp 662 - 671; DOI: 10.1021/jm00192a011 |
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Synthesis and antihypertensive activity of novel 3-hydrazino-5-phenyl-1,2,4-triazines William P. Heilman, Richard D. Heilman, James A. Scozzie, Robert J. Wayner, James M. Gullo, and Zaven S. Ariyan pp 671 - 677; DOI: 10.1021/jm00192a012 |
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Synthesis of 2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole derivatives and their central nervous system activities Yasutaka Nagai, Akira Irie, Yoshinobu Masuda, Makoto Oka, and Hitoshi Uno pp 677 - 683; DOI: 10.1021/jm00192a013 |
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Glycerides as prodrugs. 1. Synthesis and antiinflammatory activity of 1,3-bis(alkanoyl)-2-(O-acetylsalicyloyl)glycerides (aspirin triglycerides) Gerard Y. Paris, David L. Garmaise, Denis G. Cimon, Leo Swett, George W. Carter, and Patrick Young pp 683 - 687; DOI: 10.1021/jm00192a014 |
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.beta.-Adrenergic blocking agents with acute antihypertensive activity J. J. Baldwin, E. L. Engelhardt, R. Hirschmann, G. F. Lundell, G. S. Ponticello, C. T. Ludden, C. S. Sweet, A. Scriabine, N. N. Share, and R. Hall pp 687 - 694; DOI: 10.1021/jm00192a015 |
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Synthesis of some 4-substituted 8-amino-6-methoxyquinolines as potential antimalarials F. Ivy Carroll, Bertold Berrang, C. P. Linn, and Charles E. Twine pp 694 - 699; DOI: 10.1021/jm00192a016 |
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Synthesis and pharmacological evaluation of cis-3,4,4a,9a,-tetrahydro-1H-pyrano[3,4-b]benzofuran-1-ones. Tricyclic analogs related to the antilipidemic drug clofibrate Donald T. Witiak, William Loh, Dennis R. Feller, John R. Baldwin, Howard A. I. Newman, Christine L. Sober, and Richard C. Cavestri pp 699 - 705; DOI: 10.1021/jm00192a017 |
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Pyranenamines: a new series of antiallergic compounds Kenneth M. Snader, Lawrence W. Chakrin, Richard D. Cramer, Yoshiko M. Gelernt, Clara K. Miao, Dinubai H. Shah, Joseph W. Venslavsky, Chester R. Willis, and Blaine M. Sutton pp 706 - 714; DOI: 10.1021/jm00192a018 |
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Application of quantitative structure-activity relationships in the development of the antiallergic pyranenamines Richard D. Cramer, Kenneth M. Snader, Chester R. Willis, Lawrence W. Chakrin, Jean Thomas, and Blaine M. Sutton pp 714 - 725; DOI: 10.1021/jm00192a019 |
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10-(Alkylamino)-4H-thieno[3,4-b][1,5]benzodiazepines. A novel class of potential neuroleptic agents Jeffrey B. Press, Corris M. Hofmann, Nancy H. Eudy, William J. Fanshawe, Ivana P. Day, Eugene N. Greenblatt, and Sidney R. Safir pp 725 - 731; DOI: 10.1021/jm00192a020 |
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Preparation and purification of L-(.+-.)-5-formyl-5,6,7,8-tetrahydrofolic acid Carroll Temple, Robert D. Elliott, Jerry D. Rose, and John A. Montgomery pp 731 - 734; DOI: 10.1021/jm00192a021 |
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Cardioselectivity of .beta.-adrenoceptor blocking agents. 1. 1-[(4-Hydroxyphenethyl)amino]-3-(aryloxy)propan-2-ols W. J. Rzeszotarski, R. E. Gibson, W. C. Eckelman, and R. C. Reba pp 735 - 737; DOI: 10.1021/jm00192a022 |
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Conformational effects on the activity of drugs. 7. Synthesis and pharmacological properties of 2-(p-nitrophenyl)-substituted morpholines A. Balsamo, P. Crotti, A. Lapucci, B. Macchia, F. Macchia, M. Del Tacca, L. Mazzanti, and R. Ceserani pp 738 - 741; DOI: 10.1021/jm00192a023 |
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Synthesis and biological activity of 8-oxadihydropteridines Shwu-Ching Lin, Gary P. Holmes, Danny L. Dunn, and Charles G. Skinner pp 741 - 743; DOI: 10.1021/jm00192a024 |
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Synthesis and antibacterial activity of 2-oxocephalosporins C. U. Kim, P. F. Misco, and D. N. McGregor pp 743 - 745; DOI: 10.1021/jm00192a025 |
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Synthesis of imidazolidinediones and oxazolidinediones from cyclization of propargylureas and propargyl carbamates Sai-Keung Chiu, Leonard Keifer, and Jack W. Timberlake pp 746 - 748; DOI: 10.1021/jm00192a026 |
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Antiallergy activity of substituted 11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acids Charles F. Schwender, Brooks R. Sunday, David J. Herzig, Edward K. Kusner, P. R. Schumann, and Daniel L. Gawlak pp 748 - 750; DOI: 10.1021/jm00192a027 |
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Blood glucose lowering sulfonamides with asymmetric carbon atoms. 3. Related N-substituted carbamoylbenzoic acids Clemens Rufer and Wolfgang Losert pp 750 - 752; DOI: 10.1021/jm00192a028 |
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Book Reviews pp 752 - 756; DOI: 10.1021/jm00192a600 |
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Synthetic studies on β-lactam antibiotics. Part 10. Synthesis of 7β-[2-carboxy-2-(4-hydroxyphenyl)acetamido]-7.alpha.-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-1-oxa-1-dethia-3-cephem-4-carboxylic acid disodium salt (6059-S) and its related 1-oxacephems Masayuki Narisada, Tadashi Yoshida, Hiroshi Onoue, Mitsuaki Ohtani, Tetsuo Okada, Teruji Tsuji, Ikuo Kikkawa, Nobuhiro Haga, Hisashi Satoh, and et al. pp 757 - 759; DOI: 10.1021/jm00193a001 |
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Cyclopropylamines as suicide substrates for cytochromes P-450 Robert P. Hanzlik, Vimal Kishore, and Robert Tullman pp 759 - 761; DOI: 10.1021/jm00193a002 |
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Mapping the dopamine receptor. 1. Features derived from modifications in ring E of the neuroleptic butaclamol Leslie G. Humber, Francois T. Bruderlein, Adolf H. Philipp, Manfred Goetz, and Katherine Voith pp 761 - 767; DOI: 10.1021/jm00193a003 |
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Mapping the dopamine receptor. 2. Features derived from modifications in the rings A/B region of the neuroleptic butaclamol Adolf H. Philipp, Leslie G. Humber, and Katherine Voith pp 768 - 773; DOI: 10.1021/jm00193a004 |
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Peptide hormones. 137. Structural requirements in positions 1, 2, 3, and 6 of the luteinizing hormone-releasing hormone (LH-RH) for antiovulatory activity John Humphries, Yieh-Ping Wan, Tadeusz Wasiak, Karl Folkers, and Cyril Y. Bowers pp 774 - 777; DOI: 10.1021/jm00193a005 |
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Electronic structures of cephalosporins and penicillins. 9. Departure of a leaving group in cephalosporins Donald B. Boyd and W. H. W. Lunn pp 778 - 784; DOI: 10.1021/jm00193a006 |
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Mathematical considerations in series design Yvonne Connolly Martin and Helen Nehrich Panas pp 784 - 791; DOI: 10.1021/jm00193a007 |
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Computer assisted structure-activity studies of chemical carcinogens. An N-nitroso compound data set J. T. Chou and Peter C. Jurs pp 792 - 797; DOI: 10.1021/jm00193a008 |
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Actinomycin D oxazinones as improved antitumor agents Sisir K. Sengupta, Dorothy H. Trites, Maddula S. Madhavarao, and William R. Beltz pp 797 - 802; DOI: 10.1021/jm00193a009 |
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Synthesis, base-catalyzed hydrolytic reactivity, and anticancer evaluation of O-aryl phosphorodiamidates as a novel class of pro(phosphorodiamidic acid mustards) Fang-Ting Chiu, Fai-Po Tsui, and Gerald Zon pp 802 - 807; DOI: 10.1021/jm00193a010 |
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Alkylating nucleosides. 2. Synthesis and cytostatic activity of bromomethylpyrazole and pyrazole nitrogen mustard nucleosides M. Teresa Garcia-Lopez, Rosario Herranz, and Gregorio Alonso pp 807 - 811; DOI: 10.1021/jm00193a011 |
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2'-O-Acyl-6-thioinosine cyclic 3',5'-phosphates as prodrugs of thioinosinic acid Rich B. Meyer, Thomas E. Stone, and Buddy Ullman pp 811 - 815; DOI: 10.1021/jm00193a012 |
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Inhibition of rat passive cutaneous anaphylaxis by 3-(tetrazol-5-yl)quinolines Edward H. Erickson, Carol F. Hainline, Larry S. Lenon, Charles J. Matson, Thomas K. Rice, Karl F. Swingle, and Michael Van Winkle pp 816 - 823; DOI: 10.1021/jm00193a013 |
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Azaprostanoic acid derivatives. Inhibitors of arachidonic acid induced platelet aggregation D. L. Venton, Steven E. Enke, and G. C. LeBreton pp 824 - 830; DOI: 10.1021/jm00193a014 |
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Acute effects of alkylating agents on canine renal function. 1. [4-(2-Bromoalkanoyl)phenoxy]acetic acids Daniel A. Koechel, Gary O. Rankin, and William R. Sloan pp 830 - 834; DOI: 10.1021/jm00193a015 |
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Synthesis and analgesic activity of some spiro[dibenz[b,f]oxepin-10,4'-piperidine] derivatives Helen H. Ong, James A. Profitt, Theodore C. Spaulding, and Jeffrey C. Wilker pp 834 - 839; DOI: 10.1021/jm00193a016 |
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Synthesis and hypoglycemic activity of pyridylalcohols Benjamin Blank, Nicholas W. DiTullio, Arnold J. Krog, and Harry L. Saunders pp 840 - 844; DOI: 10.1021/jm00193a017 |
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Synthesis and biological activity of cocaine analogs. 2. 6H-[2]Benzopyrano[4,3-c]pyridin-6-ones Edward S. Lazer, Gilbert J. Hite, Karl A. Nieforth, and Eugene S. Stratford pp 845 - 849; DOI: 10.1021/jm00193a018 |
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Folate analogs altered in the C9-N10 bridge region: 11-thiohomofolic acid M. G. Nair, Shiang-Yuan Chen, Roy L. Kisliuk, Y. Gaumont, and D. Strumpf pp 850 - 855; DOI: 10.1021/jm00193a019 |
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2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents Daniel L. Klayman, Joseph F. Bartosevich, T. Scott Griffin, Carl J. Mason, and John P. Scovill pp 855 - 862; DOI: 10.1021/jm00193a020 |
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Analogs of methotrexate John A. Montgomery, James R. Piper, Robert D. Elliott, Carroll Temple, Eugene C. Roberts, and Y. F. Shealy pp 862 - 868; DOI: 10.1021/jm00193a021 |
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Methotrexate analogs. 12. Synthesis and biological properties of some aza homologs Jack E. Martinelli, Michael Chaykovsky, Roy L. Kisliuk, Yvette Gaumont, and Marc C. Gittelman pp 869 - 874; DOI: 10.1021/jm00193a022 |
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Synthesis of aza homologs of folic acid Jack E. Martinelli, Michael Chaykovsky, Roy L. Kisliuk, and Yvette Gaumont pp 874 - 877; DOI: 10.1021/jm00193a023 |
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Dipeptides of O-methyl-L-threonine as potential antimalarials Herman Gershon and Ira S. Krull pp 877 - 879; DOI: 10.1021/jm00193a024 |
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Some 11-substituted tetrahydrocannabinols. Synthesis and comparison with the potent cannabinoid metabolites 11-hydroxytetrahydrocannabinols Raymond S. Wilson, B. R. Martin, and W. L. Dewey pp 879 - 882; DOI: 10.1021/jm00193a025 |
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2',3'-Bis(2-chloroethyl)aminophosphoryl-3'-amino-3'-deoxyadenosine: a cyclic nucleotide with antitumor activity A. Okruszek and J. G. Verkade pp 882 - 885; DOI: 10.1021/jm00193a026 |
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Some 9-hydroxycannabinoid-like compounds. Synthesis and evaluation of analgesic and behavioral properties Raymond S. Wilson, Everett L. May, and W. L. Dewey pp 886 - 888; DOI: 10.1021/jm00193a027 |
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N-(2-Cyanoethyl) derivatives of meperidine, ketobemidone, and a potent 6,7-benzomorphan Ibrahim M. Uwaydah, M. Kathleen Waddle, and Michael E. Rogers pp 889 - 890; DOI: 10.1021/jm00193a028 |
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Active-site studies of neurohypophyseal hormones: synthesis and pharmacological properties of [5-(N4,N4-dimethylasparagine)]oxytocin Roderich Walter, Glenn L. Stahl, Themistoeles Caplaneris, Paul Cordopatis, and Dimitrios Theodoropoulos pp 890 - 893; DOI: 10.1021/jm00193a029 |
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Book Reviews pp 893 - 896; DOI: 10.1021/jm00193a600 |
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Phosphorus-31 NMR investigations of phosphoramide mustard: evaluation of pH control over the rate of intramolecular cyclization to an aziridinium ion and the hydrolysis of this reactive alkylator Thomas W. Engle, Gerald Zon, and William Egan pp 897 - 899; DOI: 10.1021/jm00194a001 |
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(+)-Isobutaclamol: a crystallographic, pharmacological, and biochemical study L. G. Humber, A. H. Philipp, K. Voith, T. Pugsley, W. Lippmann, F. R. Ahmed, and M. Przybylska pp 899 - 901; DOI: 10.1021/jm00194a002 |
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N-Alkyl derivatives of (.+-.)-.alpha.-methyldopamine Joseph G. Cannon, Zurilma Perez, John Paul Long, David B. Rusterholz, Jan R. Flynn, Brenda Costall, David H. Fortune, and Robert J. Naylor pp 901 - 907; DOI: 10.1021/jm00194a003 |
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Conformational analogs of dopamine. Synthesis and pharmacological activity of (E)- and (Z)-2-(3,4-dihydroxyphenyl)cyclopropylamine hydrochlorides Paul W. Erhardt, Richard J. Gorczynski, and William G. Anderson pp 907 - 911; DOI: 10.1021/jm00194a004 |
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Adriamycin analogs. 3. Synthesis of N-alkylated anthracyclines with enhanced efficacy and reduced cardiotoxicity George L. Tong, Helen Y. Wu, Thomas H. Smith, and David W. Henry pp 912 - 918; DOI: 10.1021/jm00194a005 |
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A phenazine analog of actinomycin D Carol W. Mosher, Daw-Yuan Lee, Rudyard M. Enanoza, Priscilla A. Sturm, and Karl F. Kuhlmann pp 918 - 922; DOI: 10.1021/jm00194a006 |
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7-(Aminoethyl) ether and thioether of daunomycinone Edward M. Acton, George L. Tong, Carol W. Mosher, Thomas H. Smith, and David W. Henry pp 922 - 926; DOI: 10.1021/jm00194a007 |
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Synthesis and biological activities of arginine-vasopressin analogs designed from a conformation-activity approach Christopher R. Botos, Clark W. Smith, Yun-Lai Chan, and Roderich Walter pp 926 - 931; DOI: 10.1021/jm00194a008 |
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Tripeptide analogs of melanocyte-stimulating hormone release-inhibiting hormone (Pro-Leu-Gly-NH2) as inhibitors of oxotremorine-induced tremor Sven Bjoerkman, Staffan Castensson, and Hans Sievertsson pp 931 - 935; DOI: 10.1021/jm00194a009 |
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Synthesis and biological activity of peptide antagonists of luliberin (luteinizing hormone-releasing hormone) G. W. Moersch, M. C. Rebstock, E. L. Wittle, F. J. Tinney, E. D. Nicolaides, M. P. Hutt, T. F. Mich, J. M. Vandenbelt, R. E. Edgren, and et al. pp 935 - 943; DOI: 10.1021/jm00194a010 |
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Synthesis of fused [1,2,6]thiadiazine 1,1-dioxides as potential transition-state analog inhibitors of xanthine oxidase and guanase Rich B. Meyer and Edward B. Skibo pp 944 - 948; DOI: 10.1021/jm00194a011 |
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3-Phenyl-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]indole-2-carbonitrile, a potent inhibitor of prostaglandin synthetase and of platelet aggregation Kenneth E. Fahrenholtz, Mary Z. Silverzweig, Nicholas Germane, Herman J. Crowley, Beverly A. Simko, and Colin Dalton pp 948 - 953; DOI: 10.1021/jm00194a012 |
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5-Fluoro-2'-deoxyuridine 5'-(p-azidophenyl phosphate), a potential photoaffinity label of thymidylate synthetase Lawrence G. Stephanson and John M. Whiteley pp 953 - 957; DOI: 10.1021/jm00194a013 |
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Synthesis of arabinofuranosyl derivatives of 3-deazaguanine Mohindar S. Poonian, Warren W. McComas, and Michael J. Kramer pp 958 - 962; DOI: 10.1021/jm00194a014 |
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Synthesis and antiestrogenic activity of [3,4-dihydro-2-(4-methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methanone, methanesulfonic acid salt Charles D. Jones, Tulio Suarez, Eddie H. Massey, Larry J. Black, and Frank C. Tinsley pp 962 - 966; DOI: 10.1021/jm00194a015 |
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Synthesis of 11.beta.,13.beta.- and 13.beta.,16.beta.-propano steroids: probes of hormonal activity Colin G. Pitt, Douglas H. Rector, Clarence E. Cook, and Mansukh C. Wani pp 966 - 970; DOI: 10.1021/jm00194a016 |
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Synthesis and biological activity of potential antimetabolites of L-fucose Jesse A. May and Alan C. Sartorelli pp 971 - 976; DOI: 10.1021/jm00194a017 |
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Vinylogous carbinolamine tumor inhibitors. 4. Antileukemic activity of derivatives of 1,2-dimethyl-3,4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate) Wayne K. Anderson and Michael J. Halat pp 977 - 980; DOI: 10.1021/jm00194a018 |
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Structure-mutagenicity relationships of N-oxidized derivatives of aniline, o-toluidine, 2'-methyl-4-aminobiphenyl, and 3,2'-dimethyl-4-aminobiphenyl Stephen S. Hecht, Karam El-Bayoumy, Lorraine Tulley, and Edmond LaVoie pp 981 - 987; DOI: 10.1021/jm00194a019 |
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Distance geometry approach to rationalizing binding data Gordon M. Crippen pp 988 - 997; DOI: 10.1021/jm00194a020 |
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Synthesis of benzo-15-crown-5 polyethers, anticoccidial ionophore analogs George R. Brown and Alan J. Foubister pp 997 - 999; DOI: 10.1021/jm00194a021 |
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Alkenylidene bisphenols, a new class of bisphenol bactericide Robert A. Conradi, James C. Vander Wyk, and Stephen B. Bowlus pp 1000 - 1002; DOI: 10.1021/jm00194a022 |
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Antimycotic imidazoles. Part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent J. Heeres, L. J. J. Backx, J. H. Mostmans, and J. Van Cutsem pp 1003 - 1005; DOI: 10.1021/jm00194a023 |
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Antimalarials. 11. Synthesis of 3- and 5-aminoquinolines as potential antimalarials M. Sami Khan and M. P. LaMontagne pp 1005 - 1008; DOI: 10.1021/jm00194a024 |
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Adamantylthiourea derivatives as antiviral agents Jefferson W. Tilley, Paul Levitan, and Michael J. Kramer pp 1009 - 1010; DOI: 10.1021/jm00194a025 |
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Nicotinamide adenine dinucleotide phosphate-decanaldehyde adduct as an inhibitor of beef brain NADP-linked aldehyde reductase John F. Towell, V. Gene Erwin, and Richard A. Deitrich pp 1011 - 1014; DOI: 10.1021/jm00194a026 |
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Partial synthesis of 6'-hydroxycinchonine and its antiarrhythmic activity in mice LaVerne D. Small, Harry Rosenberg, Peter U. Nwangwu, Terry L. Holcslaw, and Sidney J. Stohs pp 1014 - 1016; DOI: 10.1021/jm00194a027 |
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Hexofuranosyladenine nucleosides as substrates and inhibitors of calf intestional adenosine deaminase Alan J. Grant and Leon M. Lerner pp 1016 - 1018; DOI: 10.1021/jm00194a028 |
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BLEDTA: tumor localization by a bleomycin analog containing a metal-chelating group Leslie H. DeRiemer, Claude F. Meares, David A. Goodwin, and Carol I. Diamanti pp 1019 - 1023; DOI: 10.1021/jm00195a001 |
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Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones K. C. Murdock, R. G. Child, P. F. Fabio, Robert D. Angier, Roslyn E. Wallace, Frederick E. Durr, and R. V. Citarella pp 1024 - 1030; DOI: 10.1021/jm00195a002 |
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Synthesis and biological evaluation of tetramisole analogs as inhibitors of alkaline phosphatase of the 6-thiopurine-resistant tumor sarcoma 180/TG Chauder Li, Men Hui Lee, and Alan C. Sartorelli pp 1030 - 1033; DOI: 10.1021/jm00195a003 |
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Structural analogs of L-glutamic acid .gamma.-(4-hydroxyanilide) and .gamma.-(3,4-dihydroxyanilide) as potential agents against melanoma A. Rosowsky, M. M. Wick, and S. H. Kim pp 1034 - 1037; DOI: 10.1021/jm00195a004 |
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Angiotensin II analogs. 12. Role of the aromatic ring of position 8 phenylalanine in pressor activity Kun-Hwa Hsieh, Eugene C. Jorgensen, and Thomas C. Lee pp 1038 - 1044; DOI: 10.1021/jm00195a005 |
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Angiotensin II analogs. 13. Role of the hydroxyl group of position 4 tyrosine in pressor activity Kun-Hwa Hsieh, Ilona C. Kiraly-Olah, Eugene C. Jorgensen, and Thomas C. Lee pp 1044 - 1047; DOI: 10.1021/jm00195a006 |
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Photoaffinity labeling of the angiotensin II receptor. 3. Receptor inactivation with photolabile hormone analogs Emanuel H. F. Escher and Gaetan Guillemette pp 1047 - 1050; DOI: 10.1021/jm00195a007 |
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Synthesis and biological properties of N2-substituted spin-labeled analogs of actinomycin D Birandra K. Sinha, Michael G. Cox, Colin F. Chignell, and Richard L. Cysyk pp 1051 - 1055; DOI: 10.1021/jm00195a008 |
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Antifungal agents. 5. Chemical modification of antibiotics from Polyangium cellulosum var fulvum. Alcohol, ketone, aldehyde and oxime analogs of ambruticin David T. Connor and Maximillian Von Strandtmann pp 1055 - 1059; DOI: 10.1021/jm00195a009 |
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Fluorinated retinoic acids and their analogs. 1. Synthesis and biological activity of (4-methoxy-2,3,6-trimethylphenyl)nonatetraenoic acid analogs Beverly A. Pawson, Ka-Kong Chan, James DeNoble, Ru Jen L. Han, Virginia Piermattie, Anthony C. Specian, Srisamorn Srisethnil, Patrick W. Trown, Oksana Bohoslawec, and et al. pp 1059 - 1067; DOI: 10.1021/jm00195a010 |
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(Aryloxy)[p-(aryloxy)phenyl]- and (aryloxy)[p-(arylthio)phenyl]acetic acids and esters as hypolipidemic agents Ronald I. Trust, Francis J. McEvoy, and J. Donald Albright pp 1068 - 1074; DOI: 10.1021/jm00195a011 |
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Antiinflammatory agents. 1. Synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid William J. Welstead, H. Wayne Moran, Harold F. Stauffer, Lennox B. Turnbull, and Lawrence F. Sancilio pp 1074 - 1079; DOI: 10.1021/jm00195a012 |
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Syntheses of N-substituted 2(3,4)-pyridylcarboxylic acid hydrazides with analgesic and antiinflammatory activity Kinfe Redda, Linda A. Corleto, and Edward E. Knaus pp 1079 - 1082; DOI: 10.1021/jm00195a013 |
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Aromatic hydroxylation of .beta.-adrenergic antagonists. Formation of 4'- and 5'-hydroxy-1-(isopropylamino)-3-[2'-(allyloxy)phenoxy]-2-propanol from oxprenolol Wendel L. Nelson and Terrence R. Burke pp 1082 - 1088; DOI: 10.1021/jm00195a014 |
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Metabolism of .beta.-adrenergic antagonists. Evidence for an arene oxide-NIH shift pathway in the aromatic hydroxylation of oxprenolol Wendel L. Nelson and Terrence R. Burke pp 1088 - 1092; DOI: 10.1021/jm00195a015 |
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Synthesis of some carbon-3 substituted 1,4-benzodiazepin-2-ones and their central effects Tomislav Kovac, Franjo Kajfez, Vitomir Sunjic, Nikola Blazevic, and Dragutin Kolbah pp 1093 - 1096; DOI: 10.1021/jm00195a016 |
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Synthesis and biological activities of ftorafur metabolites. 3'- and 4'-Hydroxyftorafur Ai Jeng Lin, Robert S. Benjamin, Potu N. Rao, and Ti li Loo pp 1096 - 1100; DOI: 10.1021/jm00195a017 |
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Mechanism of the dealkylation of tertiary amines by hepatic oxygenases. Stable isotope studies with 1-benzyl-4-cyano-4-phenylpiperidine Robert E. McMahon, Hilman W. Culp, J. Cymerman Craig, and Nnochiri Ekwuribe pp 1100 - 1103; DOI: 10.1021/jm00195a018 |
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Anticandidal activity of 5-fluorocytosine-peptide conjugates Alvin S. Steinfeld, Fred Naider, and Jeffrey M. Becker pp 1104 - 1109; DOI: 10.1021/jm00195a019 |
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Nitrosoureidonucleosides J. A. Montgomery and H. J. Thomas pp 1109 - 1113; DOI: 10.1021/jm00195a020 |
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Antiparasitic agents. 3. Synthesis and anthelmintic activities of novel 2-pyridinyl-5-isothiocyanatobenzimidazoles R. D. Haugwitz, B. V. Maurer, G. A. Jacobs, V. L. Narayanan, L. Cruthers, and J. Szanto pp 1113 - 1118; DOI: 10.1021/jm00195a021 |
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Synthesis and antibacterial activity of 1-hydroxy-1-methyl-1,3-dihydrofuro[3,4-b]quinoxaline 4,9-dioxide and related compounds John P. Dirlam, Leonard J. Czuba, Beryl W. Dominy, Richard B. James, Richard M. Pezzullo, Joseph E. Presslitz, and Wendell W. Windisch pp 1118 - 1121; DOI: 10.1021/jm00195a022 |
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Absolute configuration of acenocoumarin Conrad R. Wheeler and William F. Trager pp 1122 - 1124; DOI: 10.1021/jm00195a023 |
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Absolute configuration of glycerol derivatives. 7. Enantiomers of 2-[[[2-(2,6-dimethoxyphenoxy)ethyl]amino]ethyl]-1,4-benzodioxane (WB-4101), a potent competitive .alpha.-adrenergic antagonist Wendel L. Nelson, Mark L. Powell, and Donald C. Dyer pp 1125 - 1127; DOI: 10.1021/jm00195a024 |
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Synthesis of angiotensin II analogs by incorporating .beta.-homotyrosine or .beta.-homoisoleucine residues K. Stachowiak, M. C. Khosla, K. Plucinska, P. A. Khairallah, and F. M. Bumpus pp 1128 - 1130; DOI: 10.1021/jm00195a025 |
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Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents Raymond A. Firestone, Judith M. Pisano, and Robert J. Bonney pp 1130 - 1133; DOI: 10.1021/jm00195a026 |
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5-[(4-Methyl-1,2,3,4-tetrahydroquinoxalyl)methyl]-2'-deoxyuridine 5'-phosphate: an analogue of a proposed intermediate in thymidylate synthetase catalysis Joon Sup Park, Charles T. C. Chang, and Mathias P. Mertes pp 1134 - 1137; DOI: 10.1021/jm00195a027 |
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5-Cyano-2'-deoxyuridine 5'-phosphate: a potent competitive inhibitor of thymidylate synthetase Charles T. C. Chang, Michael W. Edwards, Paul F. Torrence, and Mathias P. Mertes pp 1137 - 1139; DOI: 10.1021/jm00195a028 |
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Stereochemical aspects of the metabolism of 5-(4'-fluorophenyl)-5-phenylhydantoin in the rat Jacques H. Poupaert, Jacques Adline, Michel H. Claesen, Pierre De Laey, and Pierre A. Dumont pp 1140 - 1142; DOI: 10.1021/jm00195a029 |
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Antiarrhythmic activity of some N-alkylbispidinebenzamides Peter C. Ruenitz and Corwin M. Mokler pp 1142 - 1144; DOI: 10.1021/jm00195a030 |
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Antifungal agents. 4. Chemical modification of antibiotics from Polyangium cellulosum var fulvum. Ester and amide analogues of ambruticin David T. Connor and Maximillian Von Strandtmann pp 1144 - 1147; DOI: 10.1021/jm00195a031 |
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Synthesis of angiotensin II antagonists containing sarcosine in position 7 Graham J. Moore, Evelyn M. Oudeman, David Ko, and Diana M. Nystrom pp 1147 - 1149; DOI: 10.1021/jm00195a032 |
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Book Reviews pp 1149 - 1156; DOI: 10.1021/jm00195a600 |
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4-(p-Bromophenyl)-4-(dimethylamino)-1-phenethylcyclohexanol, an extremely potent representative of a new analgesic series Daniel Lednicer and Philip F. VonVoigtlander pp 1157 - 1158; DOI: 10.1021/jm00196a001 |
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(2,6-Methano-3-benzazocin-11.beta.-yl)alkanones. 1. Alkylalkanones: a new series of N-methyl derivatives with novel opiate activity profiles William F. Michne, Thomas R. Lewis, Stephen J. Michalec, Anne K. Pierson, and Franklin J. Rosenberg pp 1158 - 1163; DOI: 10.1021/jm00196a002 |
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Primaquine analogs: derivatives of 4-amino-2-methoxyacridine John P. Scovill, Daniel L. Klayman, Thomas S. Woods, and Thomas R. Sweeney pp 1164 - 1167; DOI: 10.1021/jm00196a003 |
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4-Anilidopiperidine analgesics. 2. A study of the conformational aspects of the analgesic activity of the 4-anilidopiperidines utilizing isomeric N-substituted 3-(propananilido)nortropane analogs Thomas N. Riley and Jerome R. Bagley pp 1167 - 1171; DOI: 10.1021/jm00196a004 |
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New antiarrhythmic agents. 1. Primary .alpha.-amino anilides Eugene W. Byrnes, Paul D. McMaster, Emil R. Smith, Murray R. Blair, R. Nichol Boyes, Benjamin R. Duce, Hal S. Feldman, George H. Kronberg, Bertil H. Takman, and Paul A. Tenthorey pp 1171 - 1176; DOI: 10.1021/jm00196a005 |
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New antiarrhythmic agents. 2. Amide alkyl .alpha.-amino xylidides Paul D. McMaster, Eugene W. Byrnes, Hal S. Feldman, Bertil H. Takman, and Paul A. Tenthorey pp 1177 - 1182; DOI: 10.1021/jm00196a006 |
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New antiarrhythmic agents. 3. Primary .beta.-amino anilides Paul A. Tenthorey, Robert L. DiRubio, Hal S. Feldman, Bertil H. Takman, Eugene W. Byrnes, and Paul D. McMaster pp 1182 - 1186; DOI: 10.1021/jm00196a007 |
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Troponoids. 3. Synthesis and antiallergy activity of N-troponyloxamic acid esters Jehan F. Bagli, T. Bogri, B. Palameta, R. Martel, W. Robinson, T. Pugsley, and W. Lippmann pp 1186 - 1193; DOI: 10.1021/jm00196a008 |
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Reactions of 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in aqueous solution Robert J. Weinkam and Huey-Shin Lin pp 1193 - 1198; DOI: 10.1021/jm00196a009 |
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Angiotensin II analogs. 14. Roles of the imidazole nitrogens of position-6 histidine in pressor activity Kun-Hwa Hsieh, Eugene C. Jorgensen, and Thomas C. Lee pp 1199 - 1206; DOI: 10.1021/jm00196a010 |
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Biologically active polycycloalkanes. 6. Antiviral 1-tricyclo[4.3.1.12,5]undecyl derivatives Yoshiaki Inamoto, Koji Aigami, Naotake Takaishi, Yoshiaki Fujikura, Motoyoshi Ohsugi, Hiroshi Ikeda, Kiyoshi Tsuchihashi, Akira Takatsuki, and Gakuzo Tamura pp 1206 - 1214; DOI: 10.1021/jm00196a011 |
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3-[(1,2,3-Thiadiazol-5-ylthio)methyl]cephalosporins Graham S. Lewis and Peter H. Nelson pp 1214 - 1218; DOI: 10.1021/jm00196a012 |
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Comparative cytotoxic and biochemical effects of ligands and metal complexes of .alpha.-N-heterocyclic carboxaldehyde thiosemicarbazones Leon A. Saryan, Else Ankel, Chitra Krishnamurti, David H. Petering, and Howard Elford pp 1218 - 1221; DOI: 10.1021/jm00196a013 |
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Synthesis, assignment of absolute configuration, and receptor binding studies relevant to the neuroleptic activities of a series of chiral 3-substituted cyproheptadine atropisomers William C. Randall, Paul S. Anderson, Emlen L. Cresson, Cecilia A. Hunt, Thomas F. Lyon, Kenneth E. Rittle, David C. Remy, James P. Springer, Jordan M. Hirshfield, and et al. pp 1222 - 1230; DOI: 10.1021/jm00196a014 |
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Synthesis and antitumor activity of 5-azacytosine arabinoside John A. Beisler, Mohamed M. Abbasi, and John S. Driscoll pp 1230 - 1234; DOI: 10.1021/jm00196a015 |
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Potential antitumor agents. 31. Quantitative structure-activity relationships for the antileukemic bis(guanylhydrazones) William A. Denny and Bruce F. Cain pp 1234 - 1238; DOI: 10.1021/jm00196a016 |
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Chance factors in studies of quantitative structure-activity relationships John G. Topliss and Robert P. Edwards pp 1238 - 1244; DOI: 10.1021/jm00196a017 |
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A preliminary structure-activity study of the mixed-function oxidase inhibitor, 7,8-benzoflavone Stephen Nesnow pp 1244 - 1247; DOI: 10.1021/jm00196a018 |
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Antimalarial drugs. 46. Folate antagonists. 15. 2,4-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity Edward F. Elslager, Marland P. Hutt, Patricia Jacob, Judith Johnson, Barbara Temporelli, Leslie M. Werbel, Donald F. Worth, and Leo Rane pp 1247 - 1257; DOI: 10.1021/jm00196a019 |
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Syntheses and biological activities of 7.beta.-methyl steroids Wen-Hsiung Chiu and Manfred E. Wolff pp 1257 - 1260; DOI: 10.1021/jm00196a020 |
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In vivo inhibitors of Escherichia coli phenylalanyl-tRNA synthetase Daniel V. Santi, Stephen O. Cunnion, Robert T. Anderson, and Robert W. Webster pp 1260 - 1263; DOI: 10.1021/jm00196a021 |
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Steric effects of substituents on phenethylamine hallucinogens. 3,4-(Methylenedioxy)amphetamine analogs alkylated on the dioxole ring David E. Nichols and Linda J. Kostuba pp 1264 - 1267; DOI: 10.1021/jm00196a022 |
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Structure-activity relationship of aniline mustards acting against B-16 melanoma in mice Augustine Panthananickal, Corwin Hansch, and A. Leo pp 1267 - 1269; DOI: 10.1021/jm00196a023 |
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Allylic esters as potential antitumor agents. Derivatives and analogs of 2,3-bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene Wayne K. Anderson, Richard H. Dewey, and Bipi Mulumba pp 1270 - 1272; DOI: 10.1021/jm00196a024 |
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Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives Raymond F. Schinazi, Ming S. Chen, and William H. Prusoff pp 1273 - 1277; DOI: 10.1021/jm00196a025 |
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Book Reviews pp 1277 - 1280; DOI: 10.1021/jm00196a600 |
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Sulfonated catecholamide analogs of enterobactin as iron sequestering agents Frederick L. Weitl, Wesley R. Harris, and Kenneth N. Raymond pp 1281 - 1283; DOI: 10.1021/jm00197a001 |
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Symbiotic approach to drug design: antihypertensive .beta.-adrenergic blocking agents John J. Baldwin, William C. Lumma, George F. Lundell, Gerald S. Ponticello, Andrew W. Raab, Edward L. Engelhardt, Ralph Hirschmann, Charles S. Sweet, and Alexander Scriabine pp 1284 - 1290; DOI: 10.1021/jm00197a002 |
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Ultraviolet photoelectron spectroscopy of cyclic amidines. 1. Electronic structure of some .alpha.-adrenergic benzylimidazolines A. P. De Jong and H. Van Dam pp 1290 - 1295; DOI: 10.1021/jm00197a003 |
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Structure-activity relationships of pyrroleamidine antiviral antibiotics. 1. Modifications of the alkylamidine side chain Meir Bialer, Boris Yagen, Raphael Mechoulam, and Yechiel Becker pp 1296 - 1301; DOI: 10.1021/jm00197a004 |
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Correlation of biological activity and high-pressure liquid chromatographic retention index for a series of propranolol, barbiturate, and anthranilic acid analogs John K. Baker, David O. Rauls, and Ronald F. Borne pp 1301 - 1306; DOI: 10.1021/jm00197a005 |
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Antidotes to organophosphate poisoning. 2. Thiadiazole-5-carboxaldoximes H. P. Benschop, G. R. Van den Berg, C. Van Hooidonk, L. P. A. De Jong, C. E. Kientz, F. Berends, L. A. Kepner, E. Meeter, and R. P. L. S. Visser pp 1306 - 1313; DOI: 10.1021/jm00197a006 |
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Synthesis and evaluation of the thiosemicarbazone, dithiocarbazonate, and 2'-pyrazinylhydrazone of pyrazinecarboxaldehyde as agents for the treatment of iron overload Neil E. Spingarn and Alan C. Sartorelli pp 1314 - 1316; DOI: 10.1021/jm00197a007 |
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Synthesis, redox characteristics, and in vitro norepinephrine uptake inhibiting properties of 2-(2-mercapto-4,5-dihydroxyphenyl)ethylamine (6-mercaptodopamine) Charles G. Chavdarian and Neal Castagnoli pp 1317 - 1322; DOI: 10.1021/jm00197a008 |
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Structure-activity relationships of N-substituted dopamine and 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene analogs: behavioral effects in lesioned and reserpinized mice James Z. Ginos, Janet M. Stevens, and David E. Nichols pp 1323 - 1329; DOI: 10.1021/jm00197a009 |
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Fluorinated pyrimidine nucleosides. 3. Synthesis and antitumor activity of a series of 5'-deoxy-5-fluoropyrimidine nucleosides A. F. Cook, M. J. Holman, M. J. Kramer, and P. W. Trown pp 1330 - 1335; DOI: 10.1021/jm00197a010 |
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A study of chemical carcinogenesis. 19. Synthesis and mutagenicity of 5,11-dimethylchrysene and some methyl-oxidized derivatives of 5-methylchrysene Shantilal Amin, Stephen S. Hecht, Edmond LaVoie, and Dietrich Hoffmann pp 1336 - 1340; DOI: 10.1021/jm00197a011 |
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Synthesis and biological activity of carboxyl-terminus modified prostaglandin analogs Thomas K. Schaaf and Hans Juergen Hess pp 1340 - 1346; DOI: 10.1021/jm00197a012 |
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Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 5. Conformationally mobile analogs derived by furan ring opening Lawrence L. Martin, Solomon S. Klioze, Manfred Worm, Charles A. Crichlow, Harry M. Geyer, and Hansjoerg Kruse pp 1347 - 1354; DOI: 10.1021/jm00197a013 |
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Quinolone antimicrobial agents. 2. Methylenedioxy positional isomers of oxolinic acid Lester A. Mitscher, Daniel L. Flynn, H. Eugene Gracey, and Steven D. Drake pp 1354 - 1357; DOI: 10.1021/jm00197a014 |
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Dibenzotropone- and dibenzosuberonecarboxylic acids with bronchodilator activity James P. Dunn, Dallas M. Green, Ian T. Harrison, Peter H. Nelson, Jurg R. Pfister, Adolph P. Roszkowski, and Karl G. Untch pp 1357 - 1363; DOI: 10.1021/jm00197a015 |
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Synthesis of 4-alkyl- and 4-(.beta.-alkylvinyl) derivatives of primaquine as potential antimalarials F. Ivy Carroll, Bertold D. Berrang, and C. Preston Linn pp 1363 - 1367; DOI: 10.1021/jm00197a016 |
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2-Acetylpyridine thiosemicarbazones. 2. N4,N4-Disubstituted derivatives as potential antimalarial agents Daniel L. Klayman, John P. Scovill, Joseph F. Bartosevich, and Carl J. Mason pp 1367 - 1373; DOI: 10.1021/jm00197a017 |
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Substituted 3-amino-1,1-diaryl-2-propanols as potential antidepressant agents Judith A. Clark, Michael S. G. Clark, Derek V. Gardner, Laramie M. Gaster, Michael S. Hadley, David Miller, and Anwer Shah pp 1373 - 1379; DOI: 10.1021/jm00197a018 |
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Usnic acid derivatives as potential antineoplastic agents Makoto Takai, Yoshimasa Uehara, and John A. Beisler pp 1380 - 1384; DOI: 10.1021/jm00197a019 |
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Potential antiarthritic agents. 2. Benzoylacetonitriles and .beta.-aminocinnamonitriles David N. Ridge, J. William Hanifin, Linda A. Harten, Bernard D. Johnson, Judith Menschik, Gabriela Nicolau, Adolph E. Sloboda, and Doris E. Watts pp 1385 - 1389; DOI: 10.1021/jm00197a020 |
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6-Aryl-4H-s-triazolo[4,3-a][1,4]benzodiazepines. Influence of 1-substitution on pharmacological activity Jackson B. Hester and Philip Von Voigtlander pp 1390 - 1398; DOI: 10.1021/jm00197a021 |
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Hypolipidemic activity of phthalimide derivatives. 1. N-Substituted phthalimide derivatives James M. Chapman, George H. Cocolas, and Iris H. Hall pp 1399 - 1402; DOI: 10.1021/jm00197a022 |
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Synthesis and biological evaluation of 9,11-azo-13-oxa-15-hydroxyprostanoic acid, a potent inhibitor of platelet aggregation Sheung-Tsam Kam, Philip S. Portoghese, Jonathan M. Gerrard, and Earl W. Dunham pp 1402 - 1408; DOI: 10.1021/jm00197a023 |
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Antibacterial N-[.omega.,.omega.'-bis(alicyclic and aryl)-sec-alkyl]poly(methylenetriamine and -tetramine) hydrochloride salts N. Grier, R. A. Dybas, R. A. Strelitz, B. E. Witzel, and E. L. Dulaney pp 1409 - 1414; DOI: 10.1021/jm00197a024 |
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Bufotenine esters Richard A. Glennon, Peter K. Gessner, Domodar D. Godse, and Berry J. Kline pp 1414 - 1416; DOI: 10.1021/jm00197a025 |
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Cephalosporin derivatives with 2- and 4-pyridone groups at carbon-3 M. L. Edwards and R. C. Erickson pp 1416 - 1418; DOI: 10.1021/jm00197a026 |
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Antitumor and antiinflammatory agents: N-benzoyl-protected cyanomethyl esters of amino acids Ziaodin Sajadi, Mohsen Almahmood, Larry J. Loeffler, and Iris H. Hall pp 1419 - 1422; DOI: 10.1021/jm00197a027 |
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Synthesis and antileukemic activities of furanyl, pyranyl, and ribosyl derivatives of 4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide and 3-(3,3-dimethyl-1-triazeno)pyrazole-4-carboxamide Robert A. Earl and Leroy B. Townsend pp 1422 - 1425; DOI: 10.1021/jm00197a028 |
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Synthesis and antitumor properties of 7-deoxy-7-[(cis- and trans-3-aminocyclohexane)thio]carminomycinone John M. Essery, Terrence W. Doyle, and Richard H. Schreiber pp 1425 - 1428; DOI: 10.1021/jm00197a029 |
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Nucleoside conjugates as potential antitumor agents. 2. Synthesis and biological activity of 1-.beta.-D-arabinofuranosylcytosine conjugates of prednisolone and prednisone Chung Il Hong, Alexander Nechaev, and Charles R. West pp 1428 - 1432; DOI: 10.1021/jm00197a030 |
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Book Reviews pp 1432 - 1434; DOI: 10.1021/jm00197a600 |
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N-Acetimidoyl- and N-formimidoylthienamycin derivatives: antipseudomonal .beta.-lactam antibiotics W. J. Leanza, K. J. Wildonger, T. W. Miller, and B. G. Christensen pp 1435 - 1436; DOI: 10.1021/jm00198a001 |
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Oxazepam esters. 1. Correlation between hydrolysis rates and brain appearance of oxazepam Gabor Maksay, Zsuzsanna Tegyey, Vera Kemeny, Istvan Lukovits, Laszlo Otvos, and Eva Palosi pp 1436 - 1443; DOI: 10.1021/jm00198a002 |
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Oxazepam esters. 2. Correlation of hydrophobicity with serum binding, brain penetration, and excretion Gabor Maksay, Zsuzsanna Tegyey, and Laszlo Otvos pp 1443 - 1447; DOI: 10.1021/jm00198a003 |
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Effect of structure on phenothiazine cation radical reactions in aqueous buffers Patricia Holt Sackett and Richard L. McCreery pp 1447 - 1453; DOI: 10.1021/jm00198a004 |
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Potential antitumor agents. 32. Role of agent base strength in the quantitative structure-antitumor relationships for 4'-(9-acridinylamino)methanesulfonanilide analogs William A. Denny, Graham J. Atwell, and Bruce F. Cain pp 1453 - 1460; DOI: 10.1021/jm00198a005 |
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Potential antiinflammatory compounds. 1. Antiinflammatory phenylpiperidine derivatives Terence A. Hicks, Christine E. Smith, W. R. Nigel Williamson, and Elaine H. Day pp 1460 - 1464; DOI: 10.1021/jm00198a006 |
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Potential antiinflammatory compounds. 3. Compounds derived from acenaphthene and indan Christine E. Smith, W. R. Nigel Williamson, Colin H. Cashin, and E. Ann Kitchen pp 1464 - 1469; DOI: 10.1021/jm00198a007 |
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N-Alkylated 2-aminotetralins: central dopamine-receptor stimulating activity Uli Hacksell, Uno Svensson, J. Lars G. Nilsson, Stephan Hjorth, Arvid Carlsson, Haakan Wikstroem, Per Lindberg, and Domingo Sanchez pp 1469 - 1475; DOI: 10.1021/jm00198a008 |
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N-[(Tetrahydrofuryl)alkyl] and N-(alkoxyalkyl) derivatives of (-)-normetazocine, compounds with differentiated opioid action profiles Herbert Merz and Klaus Stockhaus pp 1475 - 1483; DOI: 10.1021/jm00198a009 |
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Anticoccidial derivatives of 6-azauracil. 2. High potency and long plasma life of N1-phenyl structures Max W. Miller, Banavara L. Mylari, Harold L. Howes, John E. Lynch, Martin J. Lynch, and Richard C. Koch pp 1483 - 1487; DOI: 10.1021/jm00198a010 |
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[3-(1,4-Cyclohexadienyl)-L-alanine,8-lysine]vasopressin synthesis and some pharmacological properties Some Nath Banerjee, Lillian Diamond, Charlotte Ressler, and Wilbur H. Sawyer pp 1487 - 1492; DOI: 10.1021/jm00198a011 |
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Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines Kenneth L. Kirk, Daniele Cantacuzene, Yuthasak Nimitkitpaisan, David McCulloh, William L. Padgett, John W. Daly, and Cyrus R. Creveling pp 1493 - 1497; DOI: 10.1021/jm00198a012 |
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Synthesis and antihypertensive activity of 2-benzamido-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizines Sol S. Klioze, Frederick J. Ehrgott, Jeffrey C. Wilker, and David L. Woodward pp 1497 - 1504; DOI: 10.1021/jm00198a013 |
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Diels-Alder adducts of fulvenes and halogenated dienes. Synthesis and insecticidal activity Neil J. Lewis, David B. Knight, and William J. Collins pp 1505 - 1509; DOI: 10.1021/jm00198a014 |
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Antiestrogens and antiestrogen metabolites: preparation of tritium-labeled (.+-.)-cis-3-[p-(1,2,3,4-tetrahydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]-1,2-propanediol and characterization and synthesis of a biologically important metabolite Tochiro Tatee, Kathryn E. Carlson, John A. Katzenellenbogen, David W. Robertson, and Benita S. Katzenellenbogen pp 1509 - 1517; DOI: 10.1021/jm00198a015 |
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Electrostatic potentials of deoxydinucleoside monophosphates. 1. Deoxydinucleoside monophosphates and actinomycin chromophore interactions Merrill E. Nuss and Peter A. Kollman pp 1517 - 1524; DOI: 10.1021/jm00198a016 |
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Design of species- or isozyme-specific enzyme inhibitors. 2. Differences between a bacterial and a mammalian thymidine kinase in the effect of thymidine substituents on affinity for the thymidine site Alexander Hampton, Francis Kappler, and Ram R. Chawla pp 1524 - 1528; DOI: 10.1021/jm00198a017 |
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Design of species- or isozyme-specific enzyme inhibitors. 3. Species and isozymic differences between mammalian and bacterial adenylate kinases in substituent tolerance in an enzyme-substrate complex Alexander Hampton and Donald Picker pp 1529 - 1532; DOI: 10.1021/jm00198a018 |
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Syntheses and activities of sulfur and selenium isosteric substitution analogs of retinol Steven C. Welch and John M. Gruber pp 1532 - 1534; DOI: 10.1021/jm00198a019 |
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Synthesis of 4'- and 5'-hydroxyoxprenolol: pharmacologically active ring-hydroxylated metabolites of oxprenolol Terrence R. Burke, Wendel L. Nelson, and Carl K. Buckner pp 1535 - 1537; DOI: 10.1021/jm00198a020 |
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Synthesis and estrogenic properties of 17-epi-ethynylestradiol and its ether derivatives epimestranol and epiquinestrol Ramesh M. Kanojia, George O. Allen, Joanne M. Killinger, and J. L. McGuire pp 1538 - 1541; DOI: 10.1021/jm00198a021 |
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5-(.alpha.-Bromoacetyl)-2'-deoxyuridine 5'-phosphate: an affinity label for thymidylate synthetase Christie B. Brouillette, Charles T. C. Chang, and Mathias P. Mertes pp 1541 - 1544; DOI: 10.1021/jm00198a022 |
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Polymer-linked 6-azauridine 5'-monophosphate, a resin of high bioaffinity to orotidine-5'-phosphate decarboxylase Helmut Rosemeyer and Frank Seela pp 1545 - 1547; DOI: 10.1021/jm00198a023 |
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Derivatives of 1,3-disubstituted 2,4(1H,3H)-quinazolinediones as possible peripheral vasodilators or antihypertensive agents Herbert J. Havera pp 1548 - 1550; DOI: 10.1021/jm00198a024 |
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Dimerization of coralyne and its propyl analog and their association with DNA Alice N. Gough, Rogert L. Jones, and W. David Wilson pp 1551 - 1554; DOI: 10.1021/jm00198a025 |
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Potential antiinflammatory compounds. 2. Acidic antiinflammatory 1,2-benzisoxazoles J. C. Saunders and W. R. N. Williamson pp 1554 - 1558; DOI: 10.1021/jm00198a026 |
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Optical resolution of some homobenzomorphan derivatives and their pharmacological properties Shunsaku Shiotani, Tadashi Kometani, Tsutomu Nozawa, Akira Kurobe, and Osamu Futsukaichi pp 1558 - 1560; DOI: 10.1021/jm00198a027 |
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Book Reviews pp 1561 - 1562; DOI: 10.1021/jm00198a600 |
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Additions and Corrections - New Dopaminergic and Potential Anti-Parkinson Compounds, N,N-Disubstituted β-(3,4-Dihydroxyphenyl)ethylamines James Z. Ginos, George C. Cotzias, and David Doroski pp 1560 - 1560; DOI: 10.1021/jm00198a601 |
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Additions and Corrections - Paradoxical Effects of N-Cyano-alkyl Substituents upon the Activities of Several Classes of Opioids Arthur E. Jacobson, Kenner C. Rice, Jurgen Reden, Lillian Lupinacci, Arnold Brossi, Richard A. Streaty, and Werner A. Klee pp 1560 - 1560; DOI: 10.1021/jm00198a602 |